3 edition of Bioassay of pivalolactone for possible carcinogenicity. found in the catalog.
by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Testing Program in Bethesda, Md
Written in English
|Series||Carcinogenesis technical report series ; no. 140, DHEW publication ; no. (NIH) 79-1395, National Cancer Institute carcinogenesis technical report series -- no. 140., DHEW publication -- no. (NIH) 79-1395.|
|The Physical Object|
|Pagination||100 p. in various pagings :|
|Number of Pages||100|
GLOSSARY: Bioassay A Bioassay, also called biological standardisation, is a type of scientific experiment. Bioassays are typically conducted to measure the effects of a substance on a living organism and are essential in the development of new drugsand in monitoring environmental pollutants. Other articles where Bioassay is discussed: nanotechnology: Bioassays: A second area of intense study in nanomedicine is that of developing new diagnostic tools. Motivation for this work ranges from fundamental biomedical research at the level of single genes or cells to point-of-care applications for health delivery services. With advances in molecular biology,.
Bioassays synonyms, Bioassays pronunciation, Bioassays translation, English dictionary definition of Bioassays. bioassay - appraisal of the biological activity of a substance by testing its effect on an organism and comparing the result with some agreed standard. Daphnia laevis is a cladoceran with a wide distribution in the Americas. bioassay, radioimmunoassay are also regarded as `bioassay'. Recently `biotechnology' has also been considered for bioassay. Bioassay of the products like erythropoietin, hepatitis- B vaccine etc. is being done through biotechnology. Importance of Bioassay Bioassays, as compared to other methods of assays (e.g. chemical or physical assay) areFile Size: KB.
the 2 year rat bioassay provides little value in identifying potential carcinogenic risk. In the presenceof evidence of pharmacological, toxicological or mouse findings suggesting potential carcinogenic risk, the 2 year rat bioassay may provide information to clarify the level of risk. 8. This book presents a range of "bench top" bioassay techniques useful for natural product and pharmaceutical chemists involved in drug discovery and pharmacognosy. The contents detail a number of enzyme-based assays, cell-based functional bioassays and receptor radioligand binding assays along with detailed descriptions of each by:
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Bioassay of pivalolactone for possible carcinogenicity (OCoLC) Material Type: Government publication, National government publication: Document Type: Book: All Authors / Contributors: National Cancer Institute (U.S.).
Division of Cancer Cause and Prevention. OCLC Number: Notes: "CAS no. " Description. Additional Physical Format: Print version: National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Bioassay of pivalolactone for possible carcinogenicity.
The bioassay of pivalolactone for possible carcinogenicity was conducted using Fischer rats and B6C3F1 mice. Pivalolactone in water was administered by gavage, at either of two dosages, to groups of 50 male and 50 female animals of each species.
The high and low dosages of pivalolactone utilized were, respectively, and A bioassay of p-cresidine for possible carcinogenicity was conducted using Fischer rats and B6C3F1 mice. p-Cresidine was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species.
The dietary concentrations used in the chronic bioassay for low and high dose rats were and A bioassay of Aroclor® for possible carcinogenicity was conducted by administering the test chemical in feed to Fischer rats. Groups of 24 rats of each sex were administered Aroclor® at one of three doses, eit 50, or ppm, for weeks.
Matched controls consisted of groups of 24 untreated rats of each sex. A bioassay of beta-2'-deoxythioguanosine monohydrate (b-TGdR) for possible carcinogenicity was conducted by administering the test chemical by intraperitoneal injection to Sprague-Dawley rats and B6C3F1 mice.
Groups of 35 rats of each sex were administered b-TGdR in a buffered saline and polysorbate 80 vehicle at one of two doses, either Bioassay of ICRF for possible carcinogenicity Published: () Bioassay of sulfisoxazole for possible carcinogenicity Published: () Bioassay of estradiol mustard for possible carcinogenicity Published: ().
Bioassay of piperonyl butoxide for possible carcinogenicity Published: () Bioassays of DDT, TDE, and p, p'-DDE for possible carcinogenicity Published: () Bioassay of dixathion for possible carcinogenicity Published: (). A bioassay is an analytical method to determine concentration or potency of a substance by its effect on living cells or tissues.
Bioassays are quantitative biological assays used to estimate the potency of agents by observing their effects on living animals (in vivo) or tissue/cell culture systems (in vitro). A bioassay experiment can either be qualitative or quantitative, direct or indirect. The committee began meeting in January and selected as its first topic of study and use of the maximum tolerated dose (MTD) in animal bioassays, with emphasis on the relationship between the MTD and the carcinogenic potency of a test chemical.
To the Editor: In response to the letter by Huff () published in the December issue of Toxicological Sciences, we would like to clarify issues regarding the NTP study of Bisphenol A (BPA).Huff () states that “it appears that BPA exposure via the diet for two years should be considered associated with tumors of the hematopoietic system in rats and mice, and of the testes and of the Cited by: 7.
Bioassay for a Cancer Vaccine II Cytokine ELISA • Spike study revealed interference from the sample matrix (serum) • Serum behaved differently to ELISA diluent buffer • Expected spike conc.
≠ observed conc. • Assay failed on poor accuracy (but precision good) • Only tested 1 lot of ELISA kits from manufacturer 0 Both are procedures by which the potency or the nature of a substance is estimated by studying its effects on living matter.
Bioassay is a procedure for the determination of the concentration of a particular constitution of a mixture . Structure of Biological Assay. The typical bioassay involves a stimulus applied to a subject. Bioassay definition is - determination of the relative strength of a substance (such as a drug) by comparing its effect on a test organism with that of a standard preparation.
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Animal Carcinogenicity Studies: 3. Alternatives to the Bioassay. carcinogenicity bioassay in the general literature and the potential for the possible incorporation of alternative tests. about potential carcinogenicity; the third pro-vides direct evidence of carcinogenicity in animals; the fourth produces direct evidence about cancer in man.
These categories are brief-ly described in table Probably no statement made in the last col-umn of table 23 is free from dispute. Results may be, and frequently are, challenged for sev. bioassay (bī′ō-ăs′ā′, -ă-sā′) n. Determination of the strength or biological activity of a substance, such as a drug, by comparing its effects with those of a standard preparation on a test organism.
A test used to determine such strength or activity. tr.v. bioassayed, bioassaying, bioassays To cause to. bioassay: [ bi″o-as´a ] determination of the active power of a drug sample by comparing its effects on a live animal or an isolated organ preparation with those of a reference standard.
4. Bioassay Potency or concentration of an active principle in unit quantity of preparation by measuring its biological response on living tissues Introduced by Paul Ehrlich - biostandardization of Diphtheria antitoxin 4. Synonyms 5 Biological assay Bio. 8. In vitro techniques: • These techniques employ a cell culture of recommended biological system to study the effect of compound under standard condition not similar to that of living environment.
Here the cell culture survives by utilization of the nutrition in the media. • Ex: use of stem cells, cell culture, microbes (bacteria) etc.FUNDAMENTAL AND APPLIED TOXICOLOGY () Issues The Redundancy of Mouse Carcinogenicity Bioassays MANFRED SCHACH yon WITTENAU and PAUL C.
ESTES Department of Drug Safety Evaluation, Pfizer Central Research, Groton, CT ABSTRACT The Redundancy of Mouse Carcinogenicity by: REGULATORY TOXICOLOGY AND PHARMACOLOGY 3, () The Power and Interpretation of the Carcinogenicity Bioassay D.
B. CLAYSON,I D. KREWSKI, AND 1. C. MUNRO Health Protection Branch, Health and Welfare Canada, Ottawa, Canada Received Carcinogenicity is a major consideration in the assessment of risks due to environmental Cited by: